Musician and comedian Rob Potylo talks with his imaginary friend Locrius in episode 25 of “Quiet Desperation” — the last episode of the reality sitcom to be made for the Web before it moves to MyTV.

The local Web-based reality sitcom “Quiet Desperation” is going off the air, kind of, only to take to the actual air. Musician and comedian Rob Potylo, the founder and star of the series, and director Warren Lynch said Friday they are ending the Web series with the latest episode and restarting it in December on MyTV, where it can reach a potential 2.4 million people.

The series follows Potylo and a staggering number of other cast members — most playing exaggerated versions of themselves — as they pursue artistic, financial and romantic success in the Boston area. (Potylo has long fought for Boston to claim its spot as a creative hub alongside New York and Los Angeles, rather than having artists leave for those cities to “make it.” And Lynch is proud, and disappointed, to note the show is the area’s only totally homegrown comedy or drama.)

The series is scheduled to air at 11 p.m. Fridays starting Christmas Day, Lynch said. Episodes are to premiere every other week, then repeat in the week between.

Shows repeat more frequently with greater popularity, said Lynch, citing the frequency with which “Boston Boxing” replays.

“I’m sure we’ll get better ratings than ‘Boston Boxing,’” he said.

While there is a quietd.com, the show was crafted to appear on YouTube, meaning episodes have generally been five to 10 minutes long. The MyTV episodes will appear in half-hour slots, starting with material from the 25 finished Web shows recut into 12 to 18 shows in the broadcast format. New shows are already plotted, he said, and there should be even better continuity, although people shouldn’t expect significant changes in tone to the loose, funny, semi-improvised show.

“It’s like ‘Robot Chicken.’ They care about continuity, but people are watching to laugh,” Lynch said.

MyTV can be found on Channel 18 on Cambridge satellite and cable stations.